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KMID : 0895820090190010057
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Journal of Oriental Rehabilitation Medicine
2009 Volume.19 No. 1 p.57 ~ p.71
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Inhibitory Effect of Esubwhaltong-tang(Lishihuotong-tang) on Rheumatoid Arthritis Induced by Type Collagen
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Kim Jin-Gi
Oh Min-Seok
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Abstract
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Objectives :The aim of this study was to know the immunity reponse of Esubwhaltong-tang(hereafter referred to ESWTT) to rheumatoid arthrits in CIA(collagen induced arthritis) mice.
Methods :For this purpose, ESWTT was orally administerd to mice with arthritis induced by collagen Ⅱ and then value of immunocyte in paw joint, cytokine(IL-6, TNF-α), rheumatoid factor(IgG and IgM) and collagen II specific antibody in the serum were measured.
Results :1. The cytotoxicity was not shown on hFLSs and liver. 2. Marginal erosion, necrotic chodrocytes, cartilage and bone degradation were improved in histological section of paw joints from CIA mice(ESWTT extract administration group). 3. Total cell number of paw joint in CIA mice(ESWTT extract administration group) was decreased significantly. 4. The absolute number of CD3+, CD3+/CD69+, CD4+, CD4+/CD25+, CD49b+, CD3+/CD49b+ cells in CIA mice(ESWTT extract administration group) were decreased significantly. 5. The levels of IL-6 and TNF-α in the serum of CIA mice(ESWTT extract administration group) were decreased significantly. 6. The levels of total IgG and IgM in the serum of CIA mice(ESWTT extract administration group) were decreased significantly. 7. The level of collagen Ⅱ specific antibody in the serum of CIA mice(ESWTT extract administration group) was decreased significantly.
Conclusion :Comparison of the results for this study showed that ESWTT had immunomodulatory effects of suppressing. So we expect that ESWTT could be used as an effective drugs for not only rheumatoid arthritis but also auto-immune disease.
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KEYWORD
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Esubwhaltong-tang(ESWTT), Collagen-Ⅱ indeced arthritis, Immunocyte, Cytokine, Rheumatoid factor, Collage II specific antibody
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